Genetic Reports Deficiencies/Benefits

In reference to the recent postings about the various genetic reports and their deficiencies/benefits I’d like to make the following statement. My statement is not meant to dispute with anyone, insult anyone or anything disparaging. It is simply my opinion from years of doing this type of work.

The first thing that is necessary and needed is that anybody who obtains a genetic report is to ask themselves, “what do I expect from this report?”. If you are expecting a direct line from the polymorphisms to treatment protocols or any permutation thereof, this is simply not what is available.

As the science of genetics and nature genomics has progressed over the years, it became obvious that there was not a direct line to supplementation with reference to the polymorphisms involved. Therefore, if you have a C677T polymorphism, it does not tell you which product you need. The genetic polymorphisms give you an indicator of how that gene/enzyme will act under an oxidative stress load. Place that information within a pathway and you may have indicator of how the pathway may act under an acute or chronic oxidative stress load (reference my lecture on Chronic Inflammatory Response Syndrome given two weeks ago for AONM).

Hence, it became more efficacious over the past few years to look at things globally rather than specifically because there was a realization that you cannot change the polymorphisms but you can affect, directly or indirectly, the expression of the genetic polymorphisms (sometimes called genetic predisposition). This is based on numerous factors and not just on the snps.

I think that the angst that I’m hearing is because the expectation is that obtaining a list of the polymorphisms will answer those deep dark questions of why you may still be ill. This is a good set of data, to be sure, but it will not the answer to the entire question.

I believe that the doctor who posted these reports by name took a brave step forward because many computer applications out there at the present time will happily tell you what products to take based on your polymorphisms. If you understand what I wrote above, then it becomes clear why those other products are leading you down the garden path.

What is required to understand Stratagene or any other report for that matter, is a combination of understanding the polymorphisms and how they may affect various pathways under varying conditions, and adequate diagnostic ability (that is to say, adequate education to look at a condition holistically), adequate experience in order to have the ability to put the puzzle pieces together.

There are numerous healthcare providers in various levels of training and who have various levels of ability. To my knowledge, a database of practitioners with the appropriate information has not been created as of yet

Lastly, you’ll need to realize that if you look in the history of Dr. Ben’s work, my own, Shawn Bean’s or any of the fine healthcare providers that contribute to this field regularly; you will notice that our practices and concentrations have changed over time. It’s because we continue to study, continue to either do or read the research and because we continue to change our practices to the best interests of our patients. Hence, when I am asked what protocols I practice, my answer is usually, “protocol is a four letter word in my office” 🙂.

Again, I’m not looking to burst anyone’s bubble but I think that some are looking for a result that is not available in any genetic test.

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Dr. Jess

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